Nontoxic compounds for the treatment and prevention of herpesvirus infections

A compound set forth in Formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 comprises H, O, 2-methylthiazol, an aromatic heterocyclic group;
• or an aromatic heterocyclic group substituted by:
• a C1-C10 alkyl group;
• a halogen atom;
• a phenyl group;
• a phenyl group substituted by one or more of:
• a C1-C10 alkoxy group, and a group —CN, —NO2, —COX and —COOX, X being a C1-C4 alkyl radical;
• a group —SY, Y being a C1-C4 alkyl group or a phenyl group;
• —CN;
• a group —CH2—N3;
• a group —CH2—N3;
• an aromatic heterocyclic group selected from the group consisting of furan, thiophene, pyrrole, pyrroline, pyrrolidine, dioxolane, oxazole, thiazole, imidazole, imidazoline, imidazolidine, pyrazole, isoxazole, isothiazole, pyran, pyridine, piperidine, dioxane, morpholine, pyridazine, pyrimidine and pyrazine, each of which is optionally substituted by at least one C1-C3 alkyl radical and/or a group —CH2—N3 thereof;
• a phenyl group or a phenyl group substituted by a C1-C3 alkoxy group or NMe2;
• and,
• R2 is H, OH, CH3, halogen, C1-10 alkyl, the C1-10 alkyl is unsubstituted or optionally substituted with a functional group selected from the group consisting of H, —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF3, —OCF3, where R′ is selected from radicals consisting of H, heteroaryl having 1 to 4 N, O, halogen and/or S atoms, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C4-10 heterocycle and C4-10 heteroaryl;
• and,
• R3 is hydrogen atom, a halogen atom, a C1-C4 alkyl group, a C1-C3 alkoxy group, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl, H, —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, —O—C(O)R′, —C(O)R′, (CH2)bNH2, C(m+1)H(2m+1), C(m+1)H(2m+1)NH2, C(m+1)H(2m+1)CONH2, C(m+1)H(2m+1), CR′NH2, C(m+1)H(2m+1)—C4-20 aryl-C(m+1)H(2m+1)—NH2, CmH2m+2, C4-20 aryl, C1-20 alkyl, C1-20 alkylamino, C2-20 alkenyl, C2-20 alkynyl, C4-20 heterocycle, C4-20 heteroaryl, C4-20 alkyl heterocycle, C7-20 alkyl heteroaryl, C1-20 alkyoxyl, where m is an integer from 0 to 10, and b is an integer from 0 to 10,
• wherein,
• the C4-20 aryl, C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, C4-20 heterocycle, C4-20 heteroaryl, C4-20 alkyl heterocycle, C7-20 alkyl heteroaryl, C1-20 alkyoxyl is unsubstituted or optionally substituted with a functional group comprising H, —OH, —OR′, —NH2, —NHR′, —NR′2, —SH, —SR′, —O—C(O)R′, —C(O)R′, —CF3, or —OCF3,
• the C4-20 aryl, C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, C4-20 heterocycle, C4-20 heteroaryl, C4-20 alkyl heterocycle, C7-20 alkyl heteroaryl, C1-20 alkyoxyl, and the C1-6 alkyl is optionally interrupted by one or more O, S, or N atoms, or one or more groups comprising cycloalkyl, C(m+1)H(2m+1), C(m+1)H(2m+1)NH2, CH—C(O)—O—, —O—C(O)—, —C(O)—, —C(O)—NH—, —NH—C(O)—, —NH—C(O)—O— and —O—C(O)—NH—,
• R′ is H, OH, halogen, —CH3, NO2, —NH2, CN, —COOH, heteroaryl having 1 to 4 N, O and/or S atoms, C4-20 aryl, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, C4-10 heterocycle or C4-10 heteroaryl.

A compound of Formula IV:

• derivatives, stereoisomers, racemic or nonracemic mixture of stereoisomers, or a pharmaceutically acceptable salt thereof;
• wherein R, R′═CN, C═CH2, C≡CH, NO2, COOH, esters, Amino acids, peptides, and their corresponding salts;
• urea, thiourea, selenourea, and corresponding conjugates;
• guanidine, thioguanidine, and corresponding salts, hetrocycle (5 membered ring, 6 membered ring with N, O, S);
• and R″═H, OH, acetate, alkyl, aryl, heterocycle (5 membered, 6 membered with N, O, S).