Heterocyclic substituted-3-heteroarylidenyl-2-indolinone derivative

A compound of formula 1:

• or pharmaceutically acceptable salt thereof,
• R1 is optionally substituted heteroaryl, or optionally substituted heteroalicyclic:
• R2 is hydrogen, optionally substituted alkyl, optionally substituted alkylcarbonyl,
• optionally substituted alkoxycarbonyl, or optionally substituted aminocarbonyl;
• R3 and R4 are each independently hydrogen, halogen, cyano, nitro, hydroxy, optionally
• substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted aminocarbonyl, or the following group:
• (wherein
• X is optionally substituted five membered heteroaryl or optionally substituted heteroalicyclic,
• R8a is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic,
• R8b and R8c are each independently hydrogen, alkyl, halogen, cyano, amino, nitro, hydroxy, trifluoromethyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic, and
• n is the integral 0 to 2),
• R5 is hydrogen, halogen, cyano, nitro, hydroxy, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkylcarbonyl, optionally substituted aminocarbonyl, or the following group:
• (wherein
• Y is optionally substituted five membered heteroaryl (provided that the five membered heteroaryl is not the following group:
• wherein R9a is same as the above definition),
• R9a is optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heteroalicyclic,
• R9b and R9c are each dependently hydrogen, alkyl, halogen, cyano, amino, nitro, hydroxy, trifluoromethyl, and
• m is the integral 0 to 2), and
• at least one of R3, R4 and R5 is the following group:
• (X, R8a, R8b, R8c and n are same as the above definition), or the following group:
• (Y, R9a, R9b, R9c and m are same as the above definition);
• R6 is hydrogen, halogen, cyano, nitro, hydroxy, amino, optionally substituted alkyl, optionally substituted alkoxy, optionally substituted amino, optionally substituted alkoxycarbonyl, optionally substituted alkyl carbonyl, or optionally substituted aminocarbonyl;
• and
• R7 is hydrogen, optionally substituted alkyl, or optionally substituted cycloalkyl.