Substituted indazole derivatives active as kinase inhibitors

A compound of the formula:

• wherein:
• Ar is group of formula:
• R is aryl substituted with one or more halogen;
• R1, R2, and R3 are hydrogen;
• Ra is hydrogen, halogen, nitro, NHCOR4or NR5R6;
• Rb is hydrogen, nitro, NR5R6, OR7, or R8R9N—C1-C6 alkyl;
• R4 is hydrogen, C2-C6 alkenyl, C2-C6 alkynyl, NR5R6, OR7, SR7, R8R9N—C1-C6 alkyl, R8O—C1-C6 alkyl, an optionally further substituted straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl, aryl or heteroaryl;
• R5 and R6 are independently hydrogen, C2-C6 alkenyl, C2-C6 alkynyl, R8R9N—C2-C6 alkyl, R8O—C2-C6 alkyl, an optionally further substituted straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl, aryl or heteroaryl;
• or R5 and R6, taken together with the nitrogen atom to which they are bonded, form an optionally substituted heterocyclyl group;
• R7 is hydrogen, C2-C6 alkenyl, C2-C6 alkynyl, SOR10, SO2R10, R8R9N—C2-C6 alkyl, R8O—C2-C6 alkyl, an optionally further substituted straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl, aryl or heteroaryl;
• R8 and R9 are independently hydrogen, C2-C6 alkenyl, C2-C6 alkynyl, an optionally further substituted straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl, aryl or heteroaryl;
• or R8 and R9, taken together with the nitrogen atom to which they are bonded, may form an optionally substituted heterocyclyl group;
• and
• R10 is hydrogen, C2-C6 alkenyl, C2-C6 alkynyl, an optionally further substituted straight or branched C1-C6 alkyl, C3-C6 cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• or a pharmaceutically acceptable salt thereof.