1,3-Dihydroimidazole-2-Thione Derivatives for Use in the Treatment of Pulmonary Arterial Hypertension and Lung Injury
AssigneeBial - Portela & Ca, S.A.
InventorsPatrício Manuel Vieira Araújo SOARES DA SILVA, Maria João Macedo Da Silva BONIFÁCIO
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Abstract
The present invention relates to compounds of formula I: for use in treating pulmonary arterial hypertension and associated conditions, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl; X signifies CH2, oxygen atom or sulphur atom; n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2; and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof.
Claims20
A pharmaceutical composition comprising a compound of formula I
- wherein, R1, R2 and R3 are the same or different and signify hydrogen, halogen, alkyl, alkylaryl, alkyloxy, hydroxy, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group;
- R4 signifies hydrogen, alkyl, -alkylaryl or -alkylheteroaryl;
- X signifies CH2, oxygen atom or sulphur atom;
- n is 1, 2 or 3, with the proviso that when n is 1, X is not CH2;
- and the individual (R)- and (S)-enantiomers or mixtures of enantiomers and pharmaceutically acceptable salts thereof, in combination with at least one prostacyclin analogue.
A method of treating pulmonary arterial hypertension comprising administering a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt thereof, in combination with at least one prostacyclin analogue, to a subject in need thereof.
Dependencies are inferred from the claim text.