Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators
AssigneeSynchronicity Pharma, Inc.
InventorsRoss BERSOT, Paul HUMPHRIES
Life of this patent
Estimating the term…
Abstract
The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.
Claims28
-55. (canceled)
A compound, which is 1-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)-3-fluoropyrrolidin-2-one;
- or a pharmaceutically acceptable salt thereof.
A compound, which is 2-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)-2-azabicyclo[2.2.1]heptan-3-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is 1-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)imidazolidin-2-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is (1R,4S)-2-((R)-3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)-2-azabicyclo[2.2.1]heptan-3-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is (R)-1-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)imidazolidin-2-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is (R)-1-((R)-3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxypropyl)-3-fluoropyrrolidin-2-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is (S)-1-((S)-3-(9H-carbazol-9-yl)-2-hydroxy-2-methylpropyl)-3-fluoropyrrolidin-2-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is (R)-1-((R)-3-(9H-carbazol-9-yl)-2-hydroxypropyl)-4-methylimidazolidin-2-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
A compound, which is 1-(3-(3,6-difluoro-9H-carbazol-9-yl)-2-hydroxy-2-methylpropyl)-3,3-difluoropyrrolidin-2-one;
- or a pharmaceutically acceptable salt or hydrate thereof.
Dependencies are inferred from the claim text.