Benzyl phenyl ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof
AssigneeInstitute of Materia Medica, Chineses Academy of Medical Sciences
InventorZhiqiang Feng
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Abstract
The present invention discloses a benzyl phenyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the invention relates to benzyl phenyl ether derivatives represented by formula (I), a pharmaceutically-acceptable salt thereof, a stereoisomer thereof, a preparation method therefor, a pharmaceutical composition containing the one or more compounds, and uses of the compounds in treating diseases related to PD-1/PD-L1 signal channels, such as cancers, infectious diseases and autoimmune diseases.
Claims21
A benzyl phenyl ether derivative of Formula (I):
- or a stereoisomer or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is selected from
- R2 is selected from hydrogen, cyano, methylsulfonyl, acetylamino, carbamoyl, dimethyl amino formyl (—CON(CH3)2), fluorine, chlorine, bromine, iodine, trifluoromethyl, C1-C5 alkyl and C1-C5 alkoxy;
- R3 is selected from substituted C1-C8 saturated alkylamino, substituted C2-C6 unsaturated alkylamino, substituted N-containing C2-C6 heterocycle-1-yl, wherein each is mono-, di-, tri-, or tetra-substituted with substituent(s) selected from hydrogen, fluorine, chlorine, bromine, iodine, hydroxy, C1-C5 alkyl, C1-C5 alkoxy, amino, C1-C6 alkylamino, acetylamino, cyano, ureido (—NH(C═O)NH2), guanidino (—NH(C═NH)NH2), ureido amino (—NH—NH(C═O)NH2), guanidino amino (—NH—NH(C═NH)NH2), sulfonylamino (—NHSO3H), sulfamoyl (—SO2NH2), methanesulfonylamino (—NH—SO2CH3), hydroxyformyl (—COOH), C1-C8 alkoxyl carbonyl, sulfydryl, imidazolyl, thiazolyl, oxazolyl, tetrazolyl,
- X is selected from hydrogen, fluorine, chlorine, bromine, iodine, C1-C4 alkyl, ethenyl, trifluoromethyl, methoxy.
Dependencies are inferred from the claim text.