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US 2019/0241527 A1Published application
Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine
AssigneeArQule, Inc.
InventorsCraig BATES, Jianmin MAO, David P. REED
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Abstract
The present application relates to methods of preparing Compound A: or a salt thereof, and a polymorph of Compound A dihydrochloride salt:
Claims1
A method of making Compound A:
- or a salt thereof, comprising one or more steps selected from:
- Step 1:
- reacting Compound 1:
- with N,N-dimethylformamide dimethyl acetal (DMF-DMA), to form Compound 2:
- Step 2:
- reacting Compound 2:
- with Compound 3:
- to form Compound 4:
- Step3:
- reacting Compound 4:
- with methanesulfonyl chloride (MsCl) to form Compound 5:
- Step 4:
- reacting Compound 5:
- with methoxyethylamine to form Compound A:
11 more elements
Dependencies are inferred from the claim text.