Crystal Forms Of A 9-Aminomethyl Substituted Tetracycline Compound And A Preparation Method Thereof
AssigneeKBP Biosciences Co., Ltd.
InventorsZhenhua Huang, Mei Hong, Chen Jiang
Life of this patent
Estimating the term…
Abstract
The present invention belongs to the field of pharmaceutical technology, and crystal forms of a 9-aminomethyl substituted tetracycline compound and a process for preparing the same. More specifically, the present invention relates to crystal forms of the compound represented by formula (1), a process for preparing crystal forms of the compound represented by formula (1) and use of said crystal forms in manufacture of medicament for treating and/or preventing an infection disease caused by tetracycline-sensitive bacteria and/or tetracycline-resistant bacteria.
Claims10
Crystal forms of a compound represented by formula (1), (4S,4aS,5aR,12aS)-9-(3-azabicyclo[3.1.0]hexan-3-ylmethyl)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide,
- which are characterized by having X-ray powder diffraction patterns comprising the following characteristic peaks expressed by 2θ degree, when measured using Cu-Ka radiation:
- Crystal form I:
- 10.6°±0.2°, 13.3°±0.2°, 15.9°±0.2°, 24.0°±0.2°;
- Crystal form II:
- 10.2°±0.2°, 15.9°±0.2°, 17.9°±0.2°, 24.1°±0.2°;
- Crystal form VII:
- 11.7°±0.2°, 15.1°±0.2°, 15.9°±0.2°, 17.9°±0.2°.
Dependencies are inferred from the claim text.