Polymorphic forms of belinostat and processes for preparation thereof
AssigneeFresenius Kabi Oncology Limited
InventorsSridhar Reddy MALE, Saurabh UPADHYAY, Suneel Kumar SHARMA, Hrishikesh ACHARYA, Govind SINGH, Saswata LAHIRI, Walter CABRI
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Abstract
The present invention relates to the polymorphic forms of Belinostat. The invention also relates to the process for the preparation of the polymorphic forms of Belinostat. This invention further relates to pharmaceutical composition of said polymorphic forms of Belinostat and use thereof in the treatment of a patient in need thereof.
Claims23
An acetone solvate of Belinostat.
A process for the preparation of the acetone solvate of Belinostat, comprising the steps of:
- a. contacting Belinostat with acetone;
- and
- b. isolating the acetone solvate of Belinostat.
A crystalline form I of Belinostat, characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at about 14.7, 20.8, 21.2 and 26.4±0.2 degrees two-theta.
(canceled)
Dependencies are inferred from the claim text.