Methods and devices for the electrical stimulation of brain tissue via electrodes within cranial bone
AssigneePrecisis AG
InventorsMichael NITZERT, Jean GOTMAN, Gregor REMMERT
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Abstract
The invention features methods and devices useful for stimulating brain tissue in a subject via electrodes within cranial bone. These methods and devices may be utilized for the detection, prevention, and/or treatment of neurological disorders via electric stimulation. Additionally, the methods and devices disclosed herein may be useful for the treatment, inhibition, and/or arrestment of the growth of tumors.
Claims85
An electrostimulation device comprising a power source electrically coupled to a component comprising at least one electrode comprising one or more materials that promote osteoblast adhesion, wherein said at least one electrode comprises a cylindrical or slightly conical shape comprising a first side and a second side, wherein said at least one electrode is characterized by one or both of the following:
- (a) a cylinder length to diameter (l/d) ratio of about 0.3 to about 5.0;
- and/or
- (b) a surface roughness (Sa) of about 0.5 μm to about 3.0 μm on said second side of said at least one electrode.
A method for stimulating brain tissue in a subject, comprising:
- (i) providing an electrostimulation device comprising a power source electrically coupled to a component comprising at least one electrode;
- (ii) positioning at least a portion of said at least one electrode within cranial bone, wherein said at least one electrode comprises a first side coupled to said power source and proximate to an outer surface of said cranial bone, and a second side proximate to an inner surface of said cranial bone, wherein said second side is configured to be positioned about 0.1 mm to about 8 mm from the inner surface of said cranial bone, and wherein the inner surface of said cranial bone defines, in part, a space containing brain tissue;
- and
- (ii) delivering electrical stimulation to said brain tissue in said space.
Dependencies are inferred from the claim text.