Light-Emitting Versions of the Monoclonal Antibody to C3D (MAB 3D29) for Imaging
AssigneesThe Regents of the University of Colorado, a body corporate, The Johns Hopkins University
InventorsMartin G. Pomper, Catherine A. Foss, Joshua M. Thurman, V. Michael Holers
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Abstract
The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to C3d (mAB 3d29) for imaging and methods of use thereof for detecting infectious and inflammatory cells in vivo. The presently disclosed subject matter also provides methods for detecting and/or monitoring a Mycobacterium tuberculosis (M. tuberculosis) infection in a subject, as well as methods of treating a M. tuberculosis infection in a subject.
Claims20
A method for detecting and/or monitoring a Mycobacterium tuberculosis (M. tuberculosis) infection in a subject, the method comprising:
- (a) administering to a subject an effective amount of a monoclonal antibody or antibody derivative which binds to C3d in the subject, wherein the monoclonal antibody or antibody derivative is conjugated to an imaging tag;
- and
- (b) detecting a signal generated by the imaging tag to detect and/or monitor the location of the M. tuberculosis infection in the subject.
A method of treating a M. tuberculosis infection in a subject in need thereof, the method comprising:
- (a) administering to a subject an effective amount of a monoclonal antibody or antibody derivative which binds to C3d, wherein the monoclonal antibody or antibody derivative is conjugated to an imaging tag, and wherein the antibody or antibody derivative binds to infected tissue in the subject;
- and
- (b) detecting a signal generated by the imaging tag to detect and/or monitor the location of the M. tuberculosis infection in the subject;
- and
- (c) administering to the subject an effective amount of an antibiotic agent, an anti-inflammatory agent, or a combination thereof.
Dependencies are inferred from the claim text.