Antibody-drug conjugate
AssigneeGenahead Bio, Inc.
InventorsTsukasa SUGO, Kenichi MIYATA, Tetsuya OHTAKI
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Abstract
[Problem to be solved] The present invention provides an antibody-drug conjugate (ADC). The present invention also provides a conjugate of an anti-CD71 antibody or an antigen-binding fragment thereof with a drug. The present invention further provides a conjugate of Fab′ with a drug. The present invention further provides a composition comprising the conjugate for delivering the drug to a tissue or a cell of muscle or the like. [Solution] A conjugate of an anti-CD71 antibody or an antigen-binding fragment thereof with a drug, and a conjugate of Fab′ of an antibody with a drug.
Claims18
A conjugate of an anti-CD71 antibody or an antigen-binding fragment thereof with a drug.
Use of an anti-CD71 antibody or an antigen-binding fragment thereof, for delivering a drug to at least one selected from cardiac muscle and skeletal muscle.
An anti-CD71 antibody or antigen-binding fragment thereof, for use in delivering a drug to at least one selected from cardiac muscle and skeletal muscle.
A method for producing a conjugate of Fab′ of an anti-CD71 antibody with a drug, comprising
- reacting a thiol group of the Fab′ with a drug having a functional group reactive with the thiol group, or
- reacting a thiol group of the Fab′ with a drug bound to a linker having a functional group reactive with the thiol group.
Dependencies are inferred from the claim text.