Epinephrine formulations for medicinal products
AssigneeYs Pharmtech
InventorYosyong Surakitbanharn
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Abstract
The invention relates to compositions of epinephrine formulation in an aqueous solution that enhances the chemical stability of epinephrine and consequently extends the product shelf life. The formulation comprises epinephrine or a salt thereof, a tonicity modifier, and a complexing agent, in an aqueous solution adjusted to a pH of about 2-7. A process for manufacturing and methods of using the formulation for the medicinal products are also provided.
Claims18
An injectable pharmaceutical formulation comprising epinephrine or a salt thereof, a complexing agent, and a tonicity modifier in an aqueous solution, the injectable pharmaceutical formulation having an osmolality of about 200-400 mOsm/kg.
An injectable pharmaceutical formulation comprising epinephrine or a salt thereof, a complexing agent, and a tonicity modifier in an aqueous solution, the injectable pharmaceutical formulation having an osmolality of about 200-400 mOsm/kg, the epinephrine or a salt thereof being present in the composition in a free base equivalent amount of 0.0001 wt. % to 5 wt. %, the complexing agent being a cyclodextrin, and the molar ratio of cyclodextrin to epinephrine being in the range from 0.01:1 to 10:1.
Dependencies are inferred from the claim text.