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US 2019/0240335 A1Published application
Biocompatible Hydrogel Compositions
AssigneePromedon S.A.
InventorsKarina Bierbrauer, Roxana V. Alasino, Dante M. Beltramo, Osvaldo N. Griguol
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Abstract
The present disclosure encompasses biocompatible hydrogel compositions comprising covalently bonded hydrogel reaction products, as well as compositions of, methods of producing, methods of using, and kits comprising the covalently cross-linked hydrogel reaction products. The covalently cross-linked hydrogel reaction products can be derived from a cross-linking reaction of a polyquaternium-10, a chondroitin 4-sulfate, and a divinylsulfone.
Claims36
A composition comprising:
- a covalently cross-linked hydrogel reaction product of a cross-linking reaction of a reaction mixture comprising a polyquaternium-10, a chondroitin 4-sulfate, and a divinylsulfone, and wherein the covalently cross-linked hydrogel reaction product exhibits a gel content in the range of 65% to 85% as determined by ASTM D2765-11, 2006.
A composition comprising:
- a covalently cross-linked hydrogel reaction product of a cross-linking reaction of a reaction mixture comprising a polyquaternium-10, a chondroitin 4-sulfate, and a divinylsulfone, wherein the reaction mixture comprises the chondroitin 4-sulfate in a range of 0.2% (w/v) to 0.3% (w/v) based on volume of the reaction mixture, wherein the reaction mixture comprises the polyquaternium-10 in a range of 2% (w/v) to 3% (w/v) based on volume of the reaction mixture, wherein the reaction mixture comprises the divinylsulfone in a range of 2% (w/w) to 3% (w/w) based on combined weights of the polyquternium-10 and the chondroitin 4-sulfate in the reaction mixture, wherein the chondroitin 4-sulfate, the polyquaternium-10, and the divinylsulfone are covalently cross-linked in the covalently cross-linked hydrogel reaction product, and wherein the covalently cross-linked hydrogel reaction product exhibits a gel content in the range of 72% to 78% as determined by ASTM D2765-11, 2006.
Dependencies are inferred from the claim text.