Conjugates Comprising An Anti-EGFR1 Antibody

A polynucleotide encoding

• i) a light chain variable region and
• ii) a heavy chain variable region
• of an anti-EGFRl antibody or an EGFRl binding fragment thereof wherein the polynucleotide encoding a light chain variable region comprises or consists of the sequence set forth in SEQ ID NO:
• 8, or a sequence that is at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to SEQ ID NO:
• 8, and the polynucleotide encoding a heavy chain variable region comprises or consists of the sequence set forth in SEQ ID NO:
• 9, or a sequence that is at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to SEQ ID NO:
• 9.

A polynucleotide encoding

• i) a light chain variable region and
• ii) a heavy chain variable region
• of an anti-EGFRl antibody or an EGFRl binding fragment thereof wherein the polynucleotide comprises or consists of the light chain sequence set forth in SEQ ID NO:
• 10, or a sequence that is at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to SEQ ID NO:
• 10, and the heavy chain sequence set forth in SEQ ID NO:
• 11, or a sequence that is at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to SEQ ID NO:
• 11.

A polynucleotide encoding

• i) a light chain variable region and
• ii) a heavy chain variable region
• of an anti-EGFRl antibody or an EGFRl binding fragment thereof wherein the polynucleotide comprises or consists of the sequence set forth in SEQ ID NO:
• 12, or a sequence that is at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to SEQ ID NO:
• 12.

A polynucleotide encoding

• i) a light chain variable region and
• ii) a heavy chain variable region
• of an anti-EGFRl antibody or an EGFRl binding fragment thereof wherein the polynucleotide comprises or consists of the sequence set forth in SEQ ID NO:
• 13, or a sequence that is at least 90%, at least 91%, at least 92%, at least 93%, at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, or at least 99% identical to SEQ ID NO:
• 13.