5-ala derivatives and use thereof

A method of treating or repressing a disease or disorder including any malignant, pre-malignant and non-malignant abnormalities responsive to photochemotherapy, including, but not limited to, tumors or other hyperproliferative conditions such as cancers, skin disorders such as psoriasis, skin cancer, or actinic keratosis, infectious diseases (e.g. viral, bacterial, fungal infections), inflammatory diseases like Morbus Crohn, arthritis and rheumatoid arthritis, Barrett's oesophagus or arterial restenosis, said method comprising administering in a subject in need thereof a therapeutically effective amount of a compound according to Formula (I), a pharmaceutically acceptable salt thereof, a particle formed by said compound or a pharmaceutical formulation of said compound and exposing malignant, pre-malignant or non-malignant abnormal cells to light:

• wherein B is a biocompatible non-peptidic moiety cleavable by ubiquitous enzymes present in mammalian cells, L is a biocompatible self-removable linker and R1 is selected from H, optionally substituted C1-C30 alkyl, optionally substituted C2-C30 alkenyl, optionally substituted C2-C30 alkynyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heteroaryl and optionally substituted aryl C1-C6 alkyl and n is an integer selected from 0 and 1, wherein said biocompatible non-peptidic moiety cleavable by ubiquitous enzymes present in mammalian cells is not an acetyl group.