Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer
AssigneeMedImmune, LLC
InventorsRAJESH NARWAL, PAUL ROBBINS, JOYSON KARAKUNNEL, MOHAMMED DAR
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Abstract
Provided herein are methods of treating non-small cell lung cancers comprising administering an effective amount of MEDI4736 or an antigen-binding fragment thereof and tremelimumab or an antigen-binding fragment thereof.
Claims14
1-101. (canceled)
A method of treating non-small cell lung carcinoma (NSCLC) in a human patient, comprising administering MEDI4736 or an antigen-binding fragment thereof and tremelimumab or an antigen-binding fragment thereof to the patient, wherein the dose of MEDI4736 or an antigen-binding fragment thereof is 20-fold the dose of tremelimumab or an antigen-binding fragment thereof, wherein the MEDI4736 or an antigen-binding fragment thereof is administered about 1 hour following administration of tremelimumab or an antigen-binding fragment thereof, and wherein the MEDI4736 or an antigen-binding fragment thereof and tremelimumab or an antigen-binding fragment thereof are administered every 4 weeks for at most 16 weeks.
Dependencies are inferred from the claim text.