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US 2019/0240322 A1Published application
Method for preparation of aluminium phosphate gel for application in vaccine formulations
AssigneeBiological E Limited
InventorsRavi Ganapathy, Nagireddy Gade, Manish Manohar, Vikram Madhusadan Paradkar, Mahima Datla
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Abstract
The present invention relates to an improved process for production of Aluminium phosphate (AlPhos) gel wherein the solutions of aluminium salt and alkaline phosphate salt are added to water by maintaining the pH under stirring to obtain the precipitate, followed by sterilization of the said precipitate and finally obtaining the Aluminum phosphate gel.
Claims11
An improved process for the preparation of Aluminium Phosphate Gel which comprises of:
- i) adding the solutions of aluminium salt and alkaline phosphate salt to water by maintaining the pH between 3.0 and 4.0, under stirring to obtain a precipitate,
- ii) sterilizing the aluminum phosphate precipitate of step (i) by heating the aluminum phosphate precipitate to a temperature in the range of 120-150° C. for a period of 30 to 90 minutes;
- and
- iii) obtaining the aluminum phosphate gel having particles with a size distribution having d(50) in the range of 3.0 μm to 9.0 μm and a mean particle size less than 7 μm, wherein the process is devoid of the steps of settling the aluminum phosphate suspension and removal of supernatant.
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An improved process for the preparation of Aluminium Phosphate Gel which comprises the steps of:
- i) adding the solutions of aluminium chloride and trisodium phosphate to Water For Injection under stirring within 60 minutes, preferably between 35 to 55 minutes, by maintaining the pH of the precipitate formed between 3.0 and 4.0, preferably between 3.2 and 3.5;
- ii) sterilizing the aluminum phosphate precipitate of step (i) by heating the aluminum phosphate precipitate to a temperature in the range of 120-150° C. for a period of 30 to 90 minutes;
- and
- iii) obtaining the aluminum phosphate gel having particles with a size distribution having d(50) in the range of 3.0 μm to 9.0 μm and a mean particle size less than 7 μm, wherein the process is devoid of the steps of settling the aluminum phosphate suspension and removal of supernatant.
1 more element
Dependencies are inferred from the claim text.