Compositions and methods for the treatment or prevention of human immunodeficiency virus infection
AssigneeGlobeImmune, Inc.
InventorsThomas H. KING, David APELIAN
Life of this patent
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Abstract
Disclosed are yeast-based immunotherapeutic compositions, human immunodeficiency virus (HIV) antigens, and fusion proteins for the treatment and/or prevention of HIV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HIV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HIV and/or symptoms thereof.
Claims54
An immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) a fusion protein comprising HIV antigens, wherein the HIV antigens comprise an amino acid sequence that is at least 80% identical to SEQ ID NO:9.
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An immunotherapeutic composition comprising:
- a) a whole, inactivated yeast;
- and
- b) an HIV fusion protein comprising the amino acid sequence of SEQ ID NO:9, wherein the fusion protein is under the control of the promoter CUP1;
- wherein the HIV fusion protein is expressed by the yeast;
- and
- wherein the composition elicits an HIV-specific T cell response.
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An immunotherapeutic composition comprising:
- a) a yeast;
- and
- b) an HIV antigen expressed by the yeast and comprising an HIV Gag protein, wherein the HIV Gag protein forms very large particles (VLPs) when expressed by the yeast, wherein the HIV antigen comprises SEQ ID NO:9.
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An immunotherapeutic composition comprising:
- a) a yeast vehicle;
- and
- b) at least one HIV antigen that comprises an HIV Gag antigen comprising Sector 3 epitopes and/or Sector 1 epitopes, wherein the HIV antigen comprises SEQ ID NO:9.
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A fusion protein comprising HIV antigens, wherein the fusion protein comprises an amino acid sequence that is at least 95% identical to an amino acid sequence of:
- SEQ ID NO:9.
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Dependencies are inferred from the claim text.