Hpv vaccines
AssigneeJanssen Vaccines & Prevention B.V.
InventorsMarija VUJADINOVIC, Taco Gilles UIL, Koen OOSTERHUIS, Jort VELLINGA, Jerôme Hubertina Henricus Victor CUSTERS
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Abstract
The present invention relates to novel vaccines against Human papillomavirus (HPV) infections, based on recombinant capsid-display adenovirus vectors. Described are capsid modified replication deficient adenovirus particles encoding and displaying multiple HPV L2 antigenic fragments, via a minor capsid protein IX, and their use for eliciting an immune response in order to provide protection against infections from multiple HPV types.
Claims22
A recombinant adenoviral vector encoding a polypeptide comprising a capsid protein IX fused to an antigen wherein said antigen comprises 3 to 5 consecutive amino acid motifs, wherein each motif is about 20 to about 40 amino acids long and wherein each motif comprises an antigenic fragment of a HPV L2 protein from a different HPV type.
Dependencies are inferred from the claim text.