Synthetic immunogens for prophylaxis or treatment of tuberculosis

A composition comprising at least one nucleic acid molecule selected from the group consisting of:

• a) a nucleic acid molecule comprising three coding sequences encoding esxA,
• b) a nucleic acid molecule comprising Ag85A and esxA coding sequences,
• c) a nucleic acid molecule comprising Ag85B and esxA coding sequences,
• d) a nucleic acid molecule comprising esxH, esxA, esxU, esxS, esxD and esxV coding sequences;
• e) one or more nucleic molecules selected from the group consisting of:
• a nucleic acid molecule that comprises SEQ ID NO:11, a nucleic acid molecule that comprises SEQ ID NO:13, a nucleic acid molecule that comprises SEQ ID NO:15, a nucleic acid molecule that comprises SEQ ID NO:17, fragments thereof having at least 90% of full length, homologous sequences having at least 95% homology, and fragments of homologous sequences having at least 95% homology, said fragment of homologous sequences having at least 95% homology having at least 90% of full length;
• and
• f) one or more nucleic molecules that encodes an amino acid sequences selected from the group consisting of:
• SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18 fragments thereof having at least 90% of full length, homologous sequences having at least 95% homology, and fragments of homologous sequences having at least 95% homology, said fragment of homologous sequences having at least 95% homology having at least 90% of full length.