Anti-opioid vaccines
AssigneeThe Scripps Research Institute
InventorKim D. Janda
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Abstract
The invention provides haptens and methods of preparation thereof, for producing immunoconjugates of oxycodone and hydrocodone suitable for raising antibodies in animals specific for the opioid drugs. Administration of the opioid-speeific antibodies to humans having the opioid drugs in a body fluid such as blood serum, binds the opioid drugs to the antibody, making the opioids unavailable for producing a drug effect. Accordingly the antibodies can be used to reverse the effects of a drug overdose of oxycodone and hydrocodone, or to reverse a perceived mental effect of the drugs, such as euphoria.
Claims7
A hapten for an immunoconjugate, comprising a compound of formula (I)
- wherein R4 is H or OH.
An immunoconjugate of formula (II)
- wherein R4 is H or OH, and wherein carrier is tetanus toxoid (TT), bovine serum albumin (BSA), or a Dynabead.
Dependencies are inferred from the claim text.