Factor viii with extended half-life and reduced ligand-binding properties
AssigneeBaxalta Incorporated
InventorsPeter Turecek, Gerald Schrenk, Juergen Siekmann
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Abstract
The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to a modified, recombinant Factor VIII (FVIII) with extended half-life and reduced ligand-binding properties.
Claims1
A method of treating a hemorrhagic defect in a mammal comprising the step of administering a PSA modified FVIII, to the mammal in an amount effective to reduce or eliminate one or more symptoms of said hemorrhagic defect.
Dependencies are inferred from the claim text.