Neuromodulating compositions and related therapeutic methods for the treatment of cancer by modulating an anti-cancer immune response
AssigneeFlagship Pioneering Innovations V, Inc.
InventorsErica WEINSTEIN, Jordi MATA-FINK, Avak KAHVEJIAN, Noubar B. AFEYAN, Laura Kristina JEANBART, Alexandra LANTERMANN, Jonathan Barry HUROV, Manuel Andreas FANKHAUSER, Chengyi J. SHU, Eric Franklin ZHU
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Abstract
Described herein are methods for treating a subject having or at risk of developing cancer administering a neuromodulating agent.
Claims151
A method of treating a subject with a disease characterized by immune dysregulation, the method comprising administering to the subject an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject identified as having a disease characterized by immune dysregulation, the method comprising administering to the subject an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject with a disease characterized by immune dysregulation, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject identified as having a disease characterized by immune dysregulation, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating an immune response in a subject, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating an immune response in a subject, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating an immune cell activity, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject with cancer, the method comprising administering to the subject an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject identified as having cancer, the method comprising administering to the subject an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject with cancer, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject identified as having cancer, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject with a T cell-infiltrated tumor, the method comprising administering to the subject an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject with a T cell-infiltrated tumor, the method comprising contacting the tumor with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of treating a subject with a T cell-infiltrated tumor, the method comprising contacting a T cell in the tumor with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating innervation of a lymph node or lymphoid organ, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating innervation of a lymph node or lymphoid organ, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating development of high endothelial venules (HEVs) or ectopic or tertiary lymphoid organs (TLOs), the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating development of high endothelial venules (HEVs) or ectopic or tertiary lymphoid organs (TLOs), the method comprising administering with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating T cell cytokine production, the method comprising contacting a T cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating T cell cytokine production, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating macrophage polarization, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of modulating macrophage polarization, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing the number of immune cells in a tumor, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing the number of immune cells in a tumor, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing immune cell homing to a lymph node, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing immune cell homing to a lymph node, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing the number of CCR7+ T cells in a lymph node, the method comprising contacting a CCR7+ T cell with an effective amount of a dopamine agonist.
A method of increasing the number of CCR7+ T cells in a lymph node, the method comprising administering an effective amount of a dopamine agonist.
A method of decreasing immune cell migration to a tumor, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of decreasing immune cell migration to a tumor, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing pro-inflammatory cytokine levels, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing pro-inflammatory cytokine levels, the method comprising contacting immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing T cell production of pro-inflammatory or proliferative cytokines, the method comprising contacting a T cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing T cell production of pro-inflammatory or proliferative cytokines, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing macrophage polarization toward an M1 phenotype, the method comprising contacting a macrophage with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing macrophage polarization toward an M1 phenotype, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing immune cell cytotoxicity, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing immune cell cytotoxicity, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing Natural Killer (NK) cell activity or restoring NK cell lytic function, the method comprising contacting an NK cell with an effective amount a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing Natural Killer (NK) cell activity or restoring NK cell lytic function, the method comprising administering an effective amount a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator.
A method of increasing immune cell activation, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator, wherein the neuromodulating agent slows or prevents tumor growth.
A method of increasing immune cell activation, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator, wherein the neuromodulating agent slows or prevents tumor growth.
A method of increasing immune cell polarization toward an M1 phenotype, the method comprising contacting an immune cell with an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator, wherein the neuromodulating agent slows or prevents tumor growth.
A method of increasing immune cell polarization toward an M1 phenotype, the method comprising administering an effective amount of a neuromodulating agent selected from the group consisting of a neurotransmission modulator, a neuropeptide signaling modulator, a neuronal growth factor modulator, and a neurome gene expression modulator, wherein the neuromodulating agent slows or prevents tumor growth.
Dependencies are inferred from the claim text.