Use of compounds with thrombopoietic activity to promote bone growth and healing
AssigneeOsteofuse, Inc.
InventorsMelissa A. Kacena, Tien-Min Gabriel Chu
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Abstract
A method for treating a defect site in a living bone of an animal by applying an exogenous compound having thrombopoietic activity to the defect site in an amount effective to induce thrombopoiesis. The exogenous compound activates a thrombopoietin receptor, leading to accelerated bone formation at the defect site. Also provided is a method for repairing a segmental bone defect in an animal bone by inserting into the segmental bone defect a biodegradable bone repair scaffold that contains a compound having thrombopoietic activity. The compound activates a thrombopoietin receptor and accelerates bone formation such that bridging occurs at the segmental bone defect.
Claims22
A method for treating a defect site in a living bone of an animal, the method comprising applying a first exogenous compound having thrombopoietic activity to the defect site of the living bone in an amount effective to induce thrombopoiesis in the living bone, wherein the first exogenous compound activates a thrombopoietin receptor, thereby accelerating bone formation at the defect site.
A method for repairing a segmental bone defect in an animal bone, the method comprising providing a biodegradable bone repair scaffold that contains a first compound having thrombopoietic activity and inserting the scaffold into the segmental bone defect, wherein the first compound activates a thrombopoietin receptor, thereby accelerating bone formation such that bridging occurs at the segmental bone defect sufficient to repair the defect.
Dependencies are inferred from the claim text.