Terlipressin compositions and their methods of use
AssigneeChiasma, Inc.
InventorGary Patou
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Abstract
Methods are disclosed of treating or preventing hypotension (e.g., neurogenic orthostatic hypotension or postprandial hypotension) or portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) or ascites (e.g., ascites associated with liver cirrhosis), by oral administration to affected subjects of compositions comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof.
Claims30
A method of treating a subject suffering from a condition selected from hypotension (e.g., orthostatic hypotension, postprandial hypotension), portal hypertension (e.g., bleeding esophageal varices associated with portal hypertension) and ascites (e.g., ascites associated with liver cirrhosis), the method comprising orally administering a pharmaceutical composition configured as a tablet or capsule comprising a therapeutically effective amount of terlipressin or a pharmaceutically acceptable salt thereof, thereby treating the subject, wherein if the condition is portal hypertension (e.g. bleeding esophageal varices associated with portal hypertension) the tablet or capsule comprises 5-30 mg terlipressin and is administered 1-4 times daily.
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An oral dosage form which comprises a therapeutically effective amount of terlipressin, or a pharmaceutically acceptable salt thereof (e.g., at least 5 mg (e.g., 5, 7, 10, 15, 17, 20, 25, 30 mg)).
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Dependencies are inferred from the claim text.