Nanocage
AssigneeImperial Innovations Limited
InventorsGeoffrey Baldwin, James Field
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Abstract
The invention provides nanocages, and in particular to protein nanocages, and especially ferritin nanocages. The invention extends to variant ferritin polypeptides and their encoding nucleic acids, mutant ferritin nanocages, and their uses in diagnostics and drug delivery, as well as in phenotypic screens in drug development.
Claims33
A variant ferritin polypeptide comprising a modified amino acid sequence of a wild-type ferritin polypeptide, the modified sequence being in a dimeric subunit interface or the N-terminus of the polypeptide, wherein the variant is incapable of assembling into a ferritin nanocage unless it is contacted with a nucleating agent.
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