Method of Treating Neurological Conditions with Extract of Nerium Species or Thevetia Species
AssigneePhoenix Biotechnology, Inc.
InventorsOTIS C. ADDINGTON, ROBERT A. NEWMAN
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Abstract
A method of treating neurological condition in a subject by administration of a neuroprotective composition of a mixture of two or more triterpenes. Alzheimer's disease, Huntington's disease, stroke or Parkinson's disease are treated by administering a therapeutically effective amount of the neuroprotective composition to a subject.
Claims23
1) A neuroprotective composition consisting essentially of oleanolic acid (O), ursolic acid (U) and betulinic acid (B) as the primary or sole pharmacologically active ingredients, wherein:
- a) the neuroprotective composition excludes cardiac glycoside, and excludes pharmacologically active polysaccharide obtained from Nerium species or of Thevetia species;
- and
- b) the O, U and B are independently selected upon each occurrence from the free acid form, salt form, derivative form, prodrug form or a combination thereof.
12) A neuroprotective composition consisting essentially of oleanolic acid (O), ursolic acid (U), betulinic acid (B), and one or more other therapeutic agents, wherein:
- a) the neuroprotective composition excludes cardiac glycoside, and excludes pharmacologically active polysaccharide obtained from Nerium species or of Thevetia species;
- and
- b) the O, U and B are independently selected upon each occurrence from the free acid form, salt form, derivative form, prodrug form or a combination thereof.
Dependencies are inferred from the claim text.