Faecalibacterium longum and application thereof
AssigneeBgi Shenzhen
InventorsYuanqiang ZOU, Wenbin XUE, Liang XIAO, Chuan LIU
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Abstract
Provided are Faecalibacterium longum and an application thereof, specifically, use of Faecalibacterium longum in treating and preventing diabetes and related diseases thereof. Also provided are a composition for treating and preventing diabetes and related diseases thereof, comprising compositions of drugs, drinks, food, or animal feed, and a method for reducing weight, fasting plasma glucose and/or blood lipid, and improving glucose tolerance.
Claims12
A composition, which comprises:
- (a) a safe and effective amount of Faecalibacterium longum and/or metabolites thereof;
- and (b) a food acceptable carrier or a pharmaceutically acceptable carrier.
7. (canceled)
The method of claim 14 wherein the reduction of blood lipid level in mammals comprises the reduction of total cholesterol (TC) level and/or triglyceride level.
(canceled)
A production method, comprising the following steps:
- (a) cultivating a Faecalibacterium longum and/or metabolites thereof under a condition suitable for cultivation, thereby obtaining a culture product;
- (b) optionally, isolating Faecalibacterium longum thalluses and/or metabolites thereof from the culture product;
- and
- (c) optionally, mixing the obtained Faecalibacterium longum thalluses and/or the metabolites isolated from the previous step with a food acceptable carrier or pharmaceutically acceptable carrier, thereby obtaining a composition.
2. (canceled)
A method of treatment, which comprises a step of:
- administrating a Faecalibacterium longum and/or metabolites thereof or a composition comprising the Faecalibacterium longum and/or metabolites thereof to a subject in need, wherein the treatment is for any of the group consisting of:
- (a) prevention and/or treatment of obesity;
- (b) reduction of blood lipids;
- (c) prevention or treatment of cardiovascular disease;
- and
- (d) prevention and/or treatment of diabetes.
Faecalibacterium longum and/or metabolites thereof or a composition comprising the Faecalibacterium longum and/or metabolites thereof to a subject in need, wherein the treatment is for any of the group consisting of:
- (i) inhibition of the weight gain in mammals;
- (ii) reduction of blood lipid level in mammals;
- (iii) increase of high density lipoprotein (HDL-C) level in mammals;
- (iv) reduction of low-density lipoprotein (LDL-C) level in mammals;
- (v) reduction of blood glucose level in mammals;
- and
- (vi) increase of glucose tolerance in mammals.
Dependencies are inferred from the claim text.