Methods of testosterone therapy
OwnerGerwin WESTFIELD, Margaux ZWIERKO +2inventors
InventorsGerwin WESTFIELD, Margaux ZWIERKO, Ranjith RAMASAMY, Nathan BRYSON
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Abstract
Methods and systems for preventing or reducing side effects of testosterone replacement therapy (TRT) by administering a testosterone formulation multiple times per day are disclosed. The methods of the present invention enable men who cannot tolerate previous TRT regimens, e.g. because they wish to attempt to conceive or are at risk of developing cardiovascular side effects, to receive TRT treatment.
Claims44
A method for administering testosterone to a patient at risk of, or in need of avoiding, at least one side effect associated with testosterone replacement therapy (TRT) or a pituitary gonadotropin deficiency, the method comprising pulsatile administration of testosterone to the patient, wherein the side effect is selected from the group consisting of azoospermia, oligozoospermia, decreased libido, gynecomastia, cardiovascular disease, and cardiovascular accident.
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A method for treating a sexual disorder in a male human, the method comprising pulsatile administration of testosterone to the male human, wherein the sexual disorder is selected from the group consisting of azoospermia, oligozoospermia, decreased libido, and gynecomastia.
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A method for preventing or mitigating a side effect associated with testosterone replacement therapy (TRT) or a pituitary gonadotropin deficiency in a patient, the method comprising pulsatile administration of testosterone to the patient, wherein the side effect is selected from the group consisting of azoospermia, oligozoospermia, decreased libido, gynecomastia, cardiovascular disease, and cardiovascular accident.
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A method for increasing at least one of a level of follicle stimulating hormone (FSH), a level of luteinizing hormone (LH), and a total motile sperm count (TMSC) in a patient, comprising pulsatile administration of testosterone to the patient.
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Dependencies are inferred from the claim text.