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US 2019/0240224 A1Published application
METHODS FOR INCREASING BLOOD PLASMA 2'-DEOXYURIDINE (dUrd) AND THYMIDYLATE SYNTHASE INHIBITION
AssigneeIsofol Medical AB
InventorsGöran U. Carlsson, Bengt Gustavsson, Elisabeth Odin, Yvonne Wettergren, Anders Vedin
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Abstract
The present invention provides methods for increasing plasma dUrd levels comprising the administration of 6R-MTHF. The methods of increasing plasma dUrd increase dUrd levels compared to equimolar concentrations of LV. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF. The present invention also provides methods for increasing TS inhibition comprising the administration of 6R-MTHF.
Claims17
A method comprising:
- a. a step of administering 400 mg/m2 5-fluorouracil (5-FU) intravenously as a bolus injection to a human subject;
- b. a step of administering 60, 120, 240 mg/m2 [6R]-5,10-methylene tetrahydrofolate (6R-MTHF) intravenously as two bolus injections to said human subject approximately 30 minutes and 60 minutes following step (a);
- and
- c. a step of administering 2400 mg/m2 5-FU as a continuous infusion, either simultaneously with or following step (b).
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Dependencies are inferred from the claim text.