Deuterated compounds and medical uses thereof

Abstract

The present disclosure relates to a compound of Formula I or a non-toxic pharmaceutically acceptable salt or solvate thereof, wherein each R1, R2, R3, and R4 is independently selected from methyl (—CH3) and trideuteromethyl (—CD3), at least one of R1, R2, R3, and R4 is selected from trideuteromethyl (—CD3). The compound is a deuterated derivative of L-tetrahydropalmatine, which not only markedly improves pharmacological effects, but also significantly reduces cardiac side effects, liver toxicity, and remarkably decreases individual differences.

Dependencies are inferred from the claim text.