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US 2019/0240203 A1Published application
Novel antibiotics and methods of using same
AssigneeThe Broad Institute, Inc.
InventorJOSEPH P. VACCA
Life of this patent
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Abstract
The present invention includes novel 3,6-diazabicyclo[3.1.1]heptane antibiotic compounds and any salts or solvates thereof. The present invention further includes methods of preparing such compounds, and methods of treating bacterial infection in a subject using such compounds.
Claims10
A compound for treating or preventing bacterial infections having the structure of formula (I):
- wherein A is N or CR7;
- R1 is hydrogen or R;
- R7 is independently hydrogen, R, or F;
- and
- R2-R6 are independently selected at each occurrence from hydrogen, —X, -L1-X, or -L1-R;
- where
- —X is independently selected at each occurrence from —CN, —NH2 or —F;
- L1 is selected independently at each occurrence from —NH—, —N(R)—, —C(O)—, —(CH2)1-4—, —C(O)—N(R)—, —(C(R)2)-3—N(R)—, or —(C(R)2)1-3—;
- R is independently selected at each occurrence from hydrogen, or C1-5 linear or branched alkyl;
- wherein at least one of R2-R4 is a group -L1-R;
- or pharmaceutically acceptable salts thereof.
8 more elements
10-24. (canceled)
Dependencies are inferred from the claim text.