Non-hormonal treatment of the genitourinary syndrome of menopause
AssigneeImmugen Pharma LLC
InventorCraig R. Travis
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Abstract
Methods of treating the genitourinary syndrome of menopause (GSM) and modulating expression of genes involved in the GSM in an individual include administering compound L759,633 or compound JWH-133, both selective ligands for the endocannabinoid receptor type 2 (CB2). These compounds and compositions containing these compounds can be used as a non-hormonal alternative to hormones such as estrogen and ospemiphene for the treatment of the GSM and in particular, vaginal atrophy (VVA).
Claims21
A method of treating genitourinary syndrome of menopause in an individual comprising administering to the individual a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of:
- i) a compound having the formula:
- or
- ii) a compound having the formula:
A method of modulating an individual's vaginal microbiome comprising administering to the individual a composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of:
- i) a compound having the formula:
- or
- ii) a compound having the formula:
- wherein the therapeutically effective amount is an amount effective for at least one of:
- increasing glycogen production for promoting Lactobacillus colonization and decreasing pH in the individual's vagina, increasing RNAase7 expression for anti-bacterial activity, and increasing NLRP10 expression for anti-fungal activity.
A method of increasing or decreasing expression of any one gene from any one or more of Tables 1-9 in an individual, the method comprising:
- administering to the individual a composition comprising a pharmaceutically acceptable carrier and an amount of:
- i) a compound having the formula:
- or
- ii) a compound having the formula:
- the amount therapeutically effective for increasing or decreasing expression of any one gene from any one or more of Tables 1-9.
Dependencies are inferred from the claim text.