Tumescent infiltration drug delivery of cannabinoids
AssigneeHK Pharma
InventorsJEFFREY ALAN KLEIN, PAYTRA ALAN KLEIN
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Abstract
A tumescent composition including a cannabinoid dissolved in a tumescent solution, wherein the tumescent solution includes a local anesthetic; a vasoconstrictor; and a pharmaceutically acceptable carrier, wherein a tumescent concentration of the cannabinoid is 1-2000 μg/kg and is simultaneously: below a threshold for local, subcutaneous tissue toxicity, above a threshold for positive local therapeutic effect, and above a concentration safely achievable by intravenous (IV), intramuscular (IM) or oral (PO) delivery. Also disclosed are methods of subcutaneous delivery of a cannabinoid to a subject including administering to the subject the tumescent composition.
Claims24
A tumescent composition comprising a cannabinoid dissolved in a tumescent solution, wherein the tumescent solution consists of:
- (i) a local anesthetic;
- (ii) a vasoconstrictor;
- and
- (iii) a pharmaceutically acceptable carrier.
A tumescent composition comprising a cannabinoid dissolved in at least 500 ml of a tumescent solution, wherein the tumescent solution comprises:
- (i) a local anesthetic;
- (ii) a vasoconstrictor;
- and
- (iii) a pharmaceutically acceptable carrier,
- wherein a tumescent concentration of the cannabinoid is 1-2000 μg/kg and is simultaneously:
- 1) below a threshold for local, subcutaneous tissue toxicity,
- 2) above a threshold for positive local therapeutic effect, and
- 3) above a concentration safely achievable by intravenous
- (IV), intramuscular (IM) or oral (PO) delivery.
Dependencies are inferred from the claim text.