Small molecules against cancer

A method of modulating a biological activity of a chemokine in a subject in need thereof, the method comprising administering to the subject a compound having a general Formula VI:

• wherein:
• A′ is selected from the group consisting of —C(═O)—O—;
• —NR71—C(═O)—;
• ═C(R72)—N═;
• —C(R72)═N— and —C(R73)═C(R74)—;
• B′ is selected from the group consisting of —NR75—C(═O)—;
• —C(R76)—N═;
• —C(R76)═N—;
• —C(R77)—C(═O)—;
• and —C(R77)═C(R78)—;
• Y*1 and Y′2 are each independently selected from C-Q′, C—R79 and N, provided that at least one of Y*1 and Y′2 is C-Q′;
• Y′3 is selected from N and C—R80;
• Y′4 is selected from N and C—R81;
• R71 and R75 are each independently hydrogen or alkyl;
• R72-R74 are each independently selected from hydrogen, alkyl, alkyne, hydroxy, amine, alkoxy, aryloxy, thioalkoxy, thioaryloxy, carbonyl and carboxylate;
• R76-R78 are each independently selected from hydrogen, alkyl, hydroxy, amine, alkoxy, aryloxy, thioalkoxy, thioaryloxy, carbonyl, carboxylate, cinnamic acid, acyl, S(OH)3 and S—O—O—OH;
• R79 is hydrogen or cyano;
• R80 and R81 are each independently selected from hydrogen, hydroxy, halo, alkoxy, thioalkoxy, thiol, aryloxy, thioalkoxy, thioaryloxy, carbonyl, amine, and SO3H;
• and
• Q′ is
• wherein:
• Z′ is selected from O, NH, C(═O), S, CH2 and S(═O);
• X′1 is C(R82) or N;
• X′2 is C(R83) or N;
• X′3 is C(R84) or N;
• X′4 is C(R85) or N;
• and
• X′5 is C(R86) or N,
• provided that at least two of X71-X75 are not N,
• R82 is selected from hydrogen, alkyl and halo;
• and
• R83-R86 are each independently selected from hydrogen, halo, alkyl, amine, alkoxy, aryloxy and hydroxy;
• or, alternatively, two of R82-R86 are joined together to form an aryl or heteroaryl.

A compound presented in Table 5 and/or a compound being represented by Formula VIA:

• wherein:
• A′ is selected from the group consisting of —C(═O)—O— and —NR1—C(═O)—;
• B′ is selected from the group consisting of —NR75—C(═O)—;
• —C(R77)—C(═O)—;
• and —C(R77)═C(R78)—;
• Y′1 and Y′2 are each independently selected from C-Q′, CH and N, provided that at least one of Y′1 and Y′2 is C-Q′;
• R71 and R75 are each independently hydrogen or alkyl;
• and
• R77 and R78 are each independently hydrogen and alkyl,
• at least one of R71, R77 and R78 is an alkyl being at least 4 atoms in length;
• R80 and R81 are each independently selected from hydrogen, alkoxy, aryloxy and hydroxyl, at least one of R80 and R81 being hydroxyl or alkoxy;
• and
• Q′ is
• wherein:
• Z′ is O;
• X1 is C(R82);
• X′2 is C(R83) or N;
• X′3 is C(R84);
• X′4 is C(R85) or N;
• and
• X′5 is C(R86) or N,
• R82 is selected from hydrogen and alkyl;
• and
• R83-R86 are each independently selected from hydrogen, alkoxy, aryloxy and hydroxyl, at least one of R83-R86 being independently hydroxyl, alkoxy or aryloxy, wherein when none of X′2, X′4 or X′5 is N, then:
• A′ is —NR71—C(═O)—;
• B′ is —NR75—C(═O)—;
• and
• R71 is said alkyl being at least 4 carbon atoms in length.