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US 2019/0240177 A1Published application
Substituted bisphenyl butanoic ester derivatives as nep inhibitors
AssigneeNovartis AG
InventorsYongshuai CHAI, Sven Erik GODTFREDSEN, Mark KAGAN, Yugang LIU, Mahavir PRASHAD, Zhaoyin WANG, Saijie ZHU
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Abstract
The present disclosure provides a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.
Claims21
A compound of the Formula (I):
- wherein:
- R1 is H or (C1-C4)alkyl;
- R2 is H, (C1-C4)alkyl, (C6-C10) aryl, or 5- or 6-membered heteroaryl comprising 1-3 heteroatoms selected from N, S, and O, wherein the alkyl is optionally substituted with one or more R3, and wherein the aryl and heteroaryl are optionally substituted with one or more R4;
- each R3 is independently at each occurrence —NH2, (C1-C4)alkylamino, (C1-C4)dialkylamino, —OH, —SH, —S(C1-C4)alkyl, —CO2H, —CONH2, —NHC(NH)NH2, (C6-C10) aryl, or 5- to 10-membered monocyclic or bicyclic heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl are optionally substituted with one or more R5;
- each R4 is independently at each occurrence (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, halogen, —NH2, —OH, or CN;
- and
- each R5 is independently at each occurrence (C1-C4)alkyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, (C1-C4)haloalkoxy, halogen, —NH2, —OH, or CN;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.