Treatment of osteoarthritis
AssigneeSt. George's Hospital Medical School
InventorNidhi SOFAT
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Abstract
The present invention relates to the treatment of osteoarthritis with certain gamma-aminobutyric acid derivatives. Patients to be treated include those having elevated pain sensitivity. Specific therapies disclosed include those in which the gam-ma-aminobutyricacid derivative is administered as a single active agent rather than in combination with another active agent.
Claims27
A gamma-aminobutyric acid derivative for use in a method of treating hand osteoarthritis in a patient in need thereof, wherein said gamma-aminobutyric acid derivative is a compound of formula (I) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is a C1-6 alkyl, phenyl, or C3-6 cycloalkyl group;
- R2 is a hydrogen or methyl group;
- and
- R3 is a hydrogen, methyl, or carboxyl group.
The gamma-aminobutyric acid derivative for use according to any one of the preceding claims, wherein the patient has elevated pain sensitivity.
The gamma-aminobutyric acid derivative for use according to any one of the preceding claims, wherein the method comprises one, two or three of:
- (i) reducing hand pain in the patient;
- (ii) improving hand function in the patient;
- and
- (iii) reducing hand stiffness in the patient.
The gamma-aminobutyric acid derivative for use according to any one of the preceding claims, wherein the patient has either:
- (i) an elevated insular cortex mI/Glx ratio;
- or
- (ii) a depressed insular cortex mI/Glx ratio.
The gamma-aminobutyric acid derivative for use according to any one of the preceding claims, wherein the patient suffers from osteoarthritis in at least one joint other than joints in the hand.
The gamma-aminobutyric acid derivative for use according to any one of the preceding claims, wherein the patient suffers from at least one of knee osteoarthritis and hip osteoarthritis.
A gamma-aminobutyric acid derivative for use in a method of treating osteoarthritis in a patient in need thereof, wherein said patient has elevated pain sensitivity and wherein said gamma-aminobutyric acid derivative is a compound of formula (I) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is a C1-6 alkyl, phenyl, or C3-6 cycloalkyl group;
- R2 is a hydrogen or methyl group;
- and
- R3 is a hydrogen, methyl, or carboxyl group.
A gamma-aminobutyric acid derivative for use in a method of treating osteoarthritis in a patient in need thereof, wherein said method comprises administering the gamma-aminobutyric acid derivative as a single active agent and wherein said gamma-aminobutyric acid derivative is a compound of formula (I) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is a C1-6 alkyl, phenyl, or C3-6 cycloalkyl group;
- R2 is a hydrogen or methyl group;
- and
- R3 is a hydrogen, methyl, or carboxyl group.
A gamma-aminobutyric acid derivative for use in a method of treating osteoarthritis in a patient in need thereof, wherein said gamma-aminobutyric acid derivative is a compound of formula (I) or a pharmaceutically acceptable salt thereof
- wherein
- R1 is a C1-6 alkyl, phenyl, or C3-6 cycloalkyl group;
- R2 is a hydrogen or methyl group;
- and
- R3 is a hydrogen, methyl, or carboxyl group;
- with the proviso that said method does not comprise co-administering the gamma-aminobutyric acid derivative with meloxicam.
Dependencies are inferred from the claim text.