Modified hyaluronic acid hydrogels and proteins for the time-controlled release of biologic agents
AssigneeThe Regents of the University of California
InventorsMichael D. ROTH, Airi HARUI
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Abstract
Hyaluronic acid-based hydrogels, solutions for preparing such, and methods pertaining thereunto are disclosed with properties that include self-resorption, extended release of biologically active agents, and/or decreased degradation, denaturation, and/or functional inactivation of biologically active agents.
Claims28
A method of treating a subject, the method comprising administering to a subject a composition capable of forming a hyaluronic acid-based hydrogel, the administering comprising administering the composition as a liquid capable of in situ formation of the hydrogel, wherein the hyaluronic acid-based hydrogel formed comprises:
- a) a porous cross-linked polymeric matrix comprising 0.2% w/v to 0.8% w/v thiol-modified hyaluronic acid and 0.1% w/v to 1.2% w/v polyethylene glycol diacrylate, wherein the thiol-modified hyaluronic acid is cross-linked with the polyethylene glycol diacrylate;
- b) one or more biologically active agent(s) entrapped in the pores of the polymeric matrix;
- and
- c) a molecule with hyaluronidase activity.
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A composition capable of forming a hyaluronic acid-based hydrogel upon activation of a cross-linking reaction involving functionalized hyaluronic acid and a cross-linking agent, the composition comprising:
- functionalized hyaluronic acid;
- a cross-linking agent capable of cross-linking the functionalized hyaluronic acid;
- and
- a molecule with hyaluronidase activity.
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A kit for forming a hyaluronic acid-based hydrogel comprising:
- functionalized hyaluronic acid;
- a cross-linking agent capable of cross-linking the functionalized hyaluronic acid;
- and
- a molecule with hyaluronidase activity.
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Dependencies are inferred from the claim text.