Polymeric compositions containing ambient-temperature stable biopharmaceuticals & methods for formulation thereof
AssigneeUniversal Stabilization Technologies, Inc.
InventorVictor Bronshtein
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Abstract
Biopharmaceuticals, such as vaccine agents and probiotics, are encapsulated in carbohydrate-glass particles and embedded in an amorphous polymer substrate to produce polymeric compositions containing ambient-temperature stable biopharmaceuticals for syringeless administration to patients such as via dissolvable films, micro-needle patches and similar medical delivery devices. The amorphous polymer substrate is soluble in both water and a volatile organic solvent, yet the carbohydrate-glass particles are insoluble in the volatile organic solvent.
Claims16
A composition, comprising:
- an amorphous substrate including:
- a polymeric excipient and a plasticizer;
- and
- carbohydrate-encapsulated biopharmaceuticals embedded within said amorphous substrate;
- characterized in that:
- said polymeric excipient is soluble in both water and an organic solvent;
- and
- said carbohydrate-encapsulated biopharmaceuticals are not soluble in said organic solvent.
A composition, comprising:
- an amorphous substrate comprising between:
- 70 to 95 percent by weight hydroxypropyl cellulose and
- 5 to 30 percent by weight triacetin;
- and
- carbohydrate-encapsulated biopharmaceuticals embedded in said amorphous substrate.
A medical delivery device for delivery of biopharmaceuticals to a patient, the medical delivery device comprising:
- a vaccine agent and/or a probiotic encapsulated in carbohydrate-glass particles;
- said carbohydrate-glass particles embedded in an amorphous polymer substrate;
- wherein said amorphous polymer substrate is soluble in both water and an organic solvent;
- and
- wherein said carbohydrate-glass particles are not soluble in the organic solvent.
Dependencies are inferred from the claim text.