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US 2019/0240146 A1Published application
Adenovirus formulations
AssigneeJanssen Vaccines & Prevention B.V.
InventorJanik ADRIAANSEN
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Abstract
This disclosure provides pharmaceutical adenovirus formulations, in particular, liquid pharmaceutical formulations comprising adenoviruses.
Claims20
A formulation for adenoviruses, the formulation comprising:
- a) a recombinant adenovirus;
- b) a citrate buffer;
- c) hydroxypropyl-beta-cyclodextrin (HBCD);
- d) a salt;
- and
- e) a non-ionic detergent;
- wherein the formulation has a pH of between 5.5 and 6.5.
4 more elements
A formulation for adenoviruses, wherein the formulation has a pH of between 5.7 and 6.3, and comprises:
- a recombinant adenovirus;
- a citrate buffer at a concentration of between 5 and 30 mM;
- hydroxypropyl-beta-cyclodextrin (HBCD) at a concentration of between 1% (w/w) and 10% (w/w);
- NaCl at a concentration of between 20 mM and 200 mM;
- Polysorbate-80 at a concentration of between 0.01% (w/w) and 0.05% (w/w);
- and
- ethanol at a concentration of between 0.2% (w/w) and 0.6% (w/w),
- wherein the formulation is liquid.
5 more elements
Dependencies are inferred from the claim text.