Effervescent deferiprone tablet
AssigneeKhashayar KARIMIAN
InventorSiamak MIRTORABI
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Abstract
An oral pharmaceutical formulation for effervescent tablet of deferiprone is reported comprising of deferiprone and a taste-masking composition consisting of an effective amount of sweetener and flavoring agent and containing appropriate amount of alkali earth metal bicarbonate or carbonate and an organic carboxylic to afford a final acid pH of about 3.
Claims18
An effervescent, rapidly disintegrating oral dosage form of Deferiprone, which comprises of:
- (a) an active ingredient (Deferiprone),
- (b) an effervescent base, wherein said effervescent base and consists essentially of
- (c) a pharmaceutically acceptable auxiliary ingredient.
- (i) at least one polysaccharide sweetener,
- (ii) an edible organic add,
- (iii) an alkali metal salt, carbonate or bicarbonate of the said edible organic acid citric
The dosage form of claim 13, wherein said buccal preparation comprises from about 50 to about 1000 mg Deferiprone.
The dosage form of claim 15, wherein said sweetener is at least one of a sucrose, xylitol, D-glucose, sorbitol, mannitol, lactose, aspartame, sodium saccharine, acesulfam, and sodium cyclamate.
The process of claim 17, wherein said auxiliary ingredient is at least one of lactose, sucrose, sorbitol, mannitol, starch, pectin, or cellulose.
Dependencies are inferred from the claim text.