Bicyclic compounds
AssigneeZeno Royalties & Milestones, LLC
InventorsKevin Duane Bunker, Chuangxing Guo, Mark Charles Grier, Chad Daniel Hopkins, Joseph Robert Pinchman, Deborah Helen Slee, Peter Qinhua Huang, Mehmet Kahraman
Life of this patent
Estimating the term…
Abstract
Disclosed herein are compounds of Formulae (I) and (II), methods of synthesizing compounds of Formulae (I) and (II), and methods of using compounds of Formulae (I) and (II) as an analgesic.
Claims158
Use of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in the preparation of a medicament for reducing or at least partially preventing pain or fever, wherein Formula (I) has the structure:
- wherein:
- R1 is selected from the group consisting of H, D, a substituted or unsubstituted C1-6 alkyl and a substituted or unsubstituted C1-6 haloalkyl;
- R2 is H or C(═O)R2A;
- R2A is selected from the group consisting of H, D, a substituted or unsubstituted C1-30 alkyl, a substituted or unsubstituted C2-30 alkenyl, a substituted or unsubstituted C2-30 alkynyl, a substituted or unsubstituted C3-30 cycloalkyl, a substituted or unsubstituted C3-30 cycloalkenyl, a substituted or unsubstituted C8-30 cycloalkynyl, a substituted or unsubstituted C6-30 aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aryl(C1-6 alkyl), a substituted or unsubstituted heteroaryl(C1-6 alkyl), a substituted or unsubstituted heterocyclyl(C1-6 alkyl) and a substituted or unsubstituted C1-8 haloalkyl;
- R3 is selected from the group consisting of H, D, halo, hydroxy, a substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted C2-8 alkenyl, a substituted or unsubstituted C2-8 alkynyl, a substituted or unsubstituted C3-20 cycloalkyl, a substituted or unsubstituted C3-20 cycloalkenyl, a substituted or unsubstituted C8-20 cycloalkynyl, a substituted or unsubstituted C6-20 aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aryl(C1-6 alkyl), a substituted or unsubstituted heteroaryl(C1-6 alkyl), a substituted or unsubstituted heterocyclyl(C1-6 alkyl), a substituted or unsubstituted C1-8 haloalkyl and a substituted or unsubstituted sulfonyl;
- A1 is CR4R5;
- R4 and R5 are independently selected from the group consisting of H, D, an unsubstituted C1-8 alkyl and an unsubstituted C1-6 haloalkyl, or R4 and R5 are taken together to form an optionally substituted C3-6 cycloalkyl;
- and
- m is 0, 1, 2 or 3;
- and
- provided that when m is 0, R1 and R2 are each H, then R3 is not t-butyl;
- and a compound of Formula (I), or a pharmaceutically salt thereof is not
A compound of Formula (II), or a pharmaceutically acceptable salt thereof:
- wherein:
- R1b is H or CH3;
- R2b is CH2F, CHF2, CF3 or an unsubstituted C1-4 alkyl;
- and
- R3b is H, CH2F, CHF2, CF3, an unsubstituted C1-4 alkyl or a hydro-substituted C1-4 alkyl.
A compound selected from the group consisting of:
- or a pharmaceutically acceptable salt of the foregoing.
A method for reducing or at least partially preventing pain or fever comprising administering an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
A method for reducing or at least partially preventing pain or fever comprising administering an effective amount of a compound of Formula (II), or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
A method for reducing or at least partially preventing pain or fever comprising contacting a cell in the central and/or peripheral nervous system of a subject with an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, to a subject in need thereof.
Dependencies are inferred from the claim text.