Targeting oxazole structures for therapy against inflammatory diseases
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsRichard S. BLUMBERG, Shankar S. IYER, Thomas GENSOLLEN, Amit GANDHI
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Abstract
Described herein are novel compositions, targeted therapeutic methods, and assays for neutralizing and/or inhibiting the activity of “oxazole-containing (OxC) compounds,” to prevent or delay the onset of epithelial barrier dysfunction and chronic inflammation associated with various disorders, such as colitis.
Claims24
A pharmaceutical composition comprising an inhibitor of an Oxazole containing (OxC) compound and a pharmaceutically acceptable carrier, wherein the OxC compound is a compound of any of Formula I
- Formula II
- Formula III
- or Formula IV
- wherein R1-R14 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, alkoxy, amino, and carbonyl, provided that each of Formulas I-IV has two or more R groups which are not hydrogen.
An assay for detecting the presence of a thiazole/oxazole-modified microcin (TOMM) in a biological sample comprising measuring a level of a TOMM in a biological sample obtained from a subject, wherein if the level of a TOMM is increased at least 1.5 fold relative to a control sample, the biological sample is identified as containing a TOMM.
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Dependencies are inferred from the claim text.