Back to results
US 2019/0223814 A1Published application
18f labeled amino acids, derivatives thereof and method of making same
AssigneeSimon Fraser University
InventorsPaul SCHAFFER, Hua YANG, Robert BRITTON, Matthew NODWELL, Zheliang YUAN
Life of this patent
Estimating the term…
Abstract
The present invention provides 18F-labeled amino acids or derivatives thereof having formula (I) and methods of making same, which can be suitable for PET imaging:
Claims25
A compound having a formula (I):
- or a salt thereof or stereoisomers thereof, wherein:
- n1, n2 and n3 are independently 0-5;
- R1 is H or alkyl;
- R2 is H or alkyl;
- R3 is H, alkyl, cycloalkyl or aryl;
- R4 is H, alkyl, COR10 or R11, wherein R10 and R11 are independently an amino acid residue or peptide;
- R5 is H, alkyl, COR10 or R11, wherein R10 and R11 are independently an amino acid residue or peptide;
- R6 is —OH, or NR12R13, wherein R12 and R13 are independently H, alkyl, an amino acid residue, or a peptide residue;
- each occurrence of R7, R8 and R9 is independently H, alkyl, cycloalkyl or aryl, and wherein one or both of R1 and R2 is alkyl.
6 more elements
-5. (canceled)
(canceled)
(canceled)
A 18F-labeled compound, which is:
A process of for preparing a compound having formula:
- or a salt thereof or stereoisomers thereof, wherein:
- n1, n2 and n3 are independently 0-5;
- R1 is H or alkyl;
- R2 is H or alkyl;
- R3 is H or alkyl;
- R4 is H, alkyl, COR10 or R11, wherein R10 and R11 are independently an amino acid residue or peptide;
- R5 is H, alkyl, COR10 or R11, wherein R10 and R11 are independently an amino acid residue or peptide;
- R6 is —OH, or NR12R13, wherein R12 and R13 are independently H, alkyl, an amino acid residue, or a peptide residue;
- each occurrence of R7, R8 and R9 is independently H or alkyl;
- and
- wherein one or both of R1 and R2 is alkyl;
- comprising:
- reacting a compound of formula:
- with [18F]NFSI, in the presence of a decatungstate catalyst and a light source in an aqueous solvent.
11 more elements
Dependencies are inferred from the claim text.