Biodegradable, Antioxidant, Thermally Responsive Injectable Hydrogel and Uses Therefor
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam R. Wagner, Yasumoto Matsumura, Murugesan Velayutham, Yang Zhu
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Abstract
Provided herein are antioxidant, thermally-responsive copolymer-based compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury in a patient. The copolymer comprises a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups.
Claims20
A thermal responsive copolymer composition, comprising a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups, the copolymer having a transition temperature between 10° C. and 35° C., or between 15° C. and 30° C., above which temperature, the polymer composition transitions from an aqueous-miscible state to a higher viscosity partially-miscible or immiscible state in an aqueous solution.
A method of making an antioxidant polymer composition, comprising:
- polymerizing, using a radical polymerization method, a monomer mixture comprising vinyl pyrrolidone, an acrylate comprising a reactive group, a polyester oligomer acrylate macromer, and an N-alkyl acrylamide;
- and
- linking an antioxidant radical moiety to the reactive group.
Dependencies are inferred from the claim text.