Method for predicting acute airways obstruction of a patient with chronic respiratory disease
AssigneeRestech, Inc.
InventorAlessandro Gobbi
Life of this patent
Estimating the term…
Abstract
A method for predicting the risk of acute airways obstruction of a patient j with chronic respiratory disease, comprising the steps of: taking an already available averaged (population-based) risk curve that quantifies the probability of having a future airways obstruction in at least future days; measuring the inspiratory resistance of one patient j for at least a prefixed number of days; calculating the probability of future acute airways obstruction of the patient j, adjusting the already available averaged (population-based) risk curve with a coefficient k that take into account the inspiratory resistance of the patient j.
Claims8
A method for predicting the risk of acute airways obstruction of a patient j with chronic respiratory disease, comprising the steps of:
- a. taking an already available averaged (population-based) risk curve that quantifies the probability of having a future airways obstruction in at least future W2 days, given an input forced oscillation parameter measured for at least W1 past days during a plurality of respiratory cycles;
- b. measuring the inspiratory resistance of the patient j for at least a prefixed number of days W1 at the same or different point in time than the measurements taken for calculating the said averaged risk curve;
- c. calculating the probability of future acute airways obstruction of the patient j, for any day i, as following:
- ACP
- ADJ
- ,
- W
-
-
- 1
- ,
- W
-
-
- 2
-
- (
- j
- ,
- i
- )
- =
- ACP
- W
-
-
- 1
- ,
- W
-
-
- 2
-
- (
- i
- )
- +
- k
- W
-
-
- 1
-
- (
- j
- ,
- i
- )
- ,
-
- k
- W
-
-
- 1
-
- (
- j
- ,
- i
- )
- =
- R
- insp
- ,
- W
-
-
- 1
-
- (
- j
- ,
- i
- )
- -
- Rrs
- pred
-
- (
- j
- )
- Rrs
- pred
-
- (
- j
- )
- ·
- [
- 1
- -
- ACP
- W
-
-
- 1
- ,
- W
-
-
- 2
-
- (
- i
- )
- ]
- where:
- ACPADJ,W1,W2(j,i)=probability (risk) of future acute airways obstruction adjusted on an individual basis for the patient j on the day i;
- ACPW1,W2(i)=on the given day i, probability of future acute airways obstruction in the future W2 days for the patient j, where such probability is calculated from said available averaged population-based risk profile given the day-to-day variability of Rinsp measured in the past W1;
- Rinsp,W1(j,i)=on the given day i, average day-to-day Rinsp of the patient j, calculated from said number of past days W1;
- Rrspred(j)=predicted value of respiratory resistance, given the anthropometric characteristics of the patient j.
Dependencies are inferred from the claim text.