Systems and methods for electrochemical creatinine assays and blood urea nitrogen
OwnerBrittney Werner, Gary Hughesinventors
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Abstract
A system for the electrochemical detection of analyte levels includes a test strip including an electrode and a counter electrode, the electrode and counter electrode located proximate to a sample reception area. The system further includes a coating on one of the electrode and counter electrode, the coating including a reagent coating for an analyte. The reagent coating includes a creatinine iminohydrolase, deamido NAD+, ATP, and NAD Synthetase/Mg2+.
Claims24
A system for the electrochemical detection of an analyte level, the system comprising:
- a test strip including an electrode and a counter electrode, the electrode and counter electrode located proximate to a sample reception area;
- and
- a coating on one of the electrode and counter electrode, the coating including a reagent coating for an analyte.
The system of claim 5, wherein the reagent coating includes a surfactant and a buffer. The system of claim 6, wherein the reagent buffer includes a binder and a stabilizer.
A system for the electrochemical detection of analyte levels, the system comprising:
- a test strip including an electrode and a counter electrode, the electrode and counter electrode located proximate to a sample reception area;
- a coating on one of the electrode and counter electrode, the coating including a reagent coating for an analyte;
- and
- an analyzer for receiving the test strip and including instructions stored on a non-transitory medium for applying a current to the test strip and responsively determining an amount of the analyte.
A method for detecting a blood analyte, the method comprising:
- producing ammonia (NH3) from a first reaction;
- reacting the ammonia with deamido NAD+, ATP, and NAD Synthetase/Mg2+ to produce NAD+;
- and
- measuring a level of the blood anaylte with at least two electrodes.
A method of detecting an analyte, the method comprising:
- providing an electrochemical test strip;
- placing the electrochemical test strip in an analyzer;
- placing a blood sample on the electrochemical test strip;
- measuring a current provided through the blood sample and the electrochemical test strip;
- and
- calculating a level of an analyte, the analyte selected from the group consisting of creatinine and urea, with the analyzer based on the current.
Dependencies are inferred from the claim text.