Conversion Of Alcohols To Linear And Branched Functionalized Alkanes

The method according to any one of the previous claims, comprising the steps of:

• (i) providing the starting alcohol,
• (ii) providing an oxidant, such as air, H2O2, O2, or NaOCl,
• (iii) optionally providing an oxidizing catalyst, such as a heterogeneous supported metal catalyst, or a homogeneous organometallic complex, or a metal-free catalyst (mediator), or an oxidizing enzyme (EC 1:10:3:2) and oxidizing the starting alcohol, optionally in the presence of said oxidizing catalyst, into the corresponding aldehyde or ketone,
• (iv) providing a metal-free condensation catalyst system,
• (v) optionally including an acid or a salt thereof, and converting the corresponding aldehyde or ketone, in the presence of said condensation catalyst system, into the enal or enone,
• (vi) providing a reducing agent, such as formic acid, H2, ammonium formiate, or Hantzsch ester,
• (vii) optionally providing a reducing catalyst, such as a heterogeneous supported metal catalyst, or a homogeneous organometallic complex, or a metal-free catalyst, or a reducing enzyme and reducing the enal or enone, optionally in the presence of said reducing catalyst, into the product.

The method according to any one of the previous claims, comprising:

• (i) providing the starting alcohol,
• (ii) providing an oxidant, such as air, O2, or NaClO,
• (iii) optionally providing an oxidation catalysts system, such as TEMPO, CuBr, bpy, NMI, O2;
• or TEMPO, HNO3, HCl, O2;
• or TEMPO, NaOCl, KBr;
• or a heterogeneous supported metal catalyst (Pd, Ag, Ru, Ir, or Fe);
• or a homogeneous catalyst system (Pd, Ag, Ru, Ir, or Fe) and converting the starting alcohol, optionally in the presence of said oxidation catalyst system, into the corresponding aldehyde or ketone,
• (iv) providing an amine catalyst system or a salt thereof,
• (v) optionally including an acid, and converting the corresponding aldehyde or ketone, in the presence of said amine catalyst system or the salt thereof, optionally including an acid, into the enal or enone,
• (vi) providing a reducing agent, such as formic acid, H2, or ammonium formiate,
• (vii) optionally providing a reducing catalyst which is heterogeneous supported metal catalyst (Pd, Ag, Ru, Ir, Fe, Ni, or Co), or a homogeneous organometallic complex (Pd, Ag, Ru, Ir, Fe, Ni, or Co);
• and reducing the enal or enone, optionally in the presence of said reducing catalyst, into the product.