Method for predicting responsiveness to phosphatidylserine synthase 1 inhibitor
AssigneeDaiichi Sankyo Company, Limited
InventorsYohei YOSHIHAMA, Tatsuya INOUE
Life of this patent
Estimating the term…
Abstract
It is intended to develop a therapeutic strategy for specifically targeting cancer cells having the functional suppression of PSS2. The present inventors have found that PSS1 and PSS2 are in a synthetic lethal relationship, and treatment inhibiting PSS1 serves as a promising approach for the treatment of cancer having the functional suppression of PSS2. It has also been revealed that this therapeutic strategy permits efficient treatment based on companion diagnostics because a PSS1 inhibitor can be administered to a subject selected by using the functional suppression of PSS2 as an index.
Claims9
A method for predicting responsiveness to the treatment of cancer with a phosphatidylserine synthase 1 inhibitor, comprising providing a biological sample derived from a subject, detecting the presence or absence of the functional suppression of phosphatidylserine synthase 2 in the biological sample, and thereby determining that the subject for whom the functional suppression of phosphatidylserine synthase 2 has been detected has responsiveness to the treatment of cancer with a phosphatidylserine synthase 1 inhibitor.
A method for selecting a subject for the treatment of cancer with a phosphatidylserine synthase 1 inhibitor, comprising providing a biological sample derived from a subject, detecting the presence or absence of the functional suppression of phosphatidylserine synthase 2 in the biological sample, and selecting the subject for whom the functional suppression of phosphatidylserine synthase 2 has been detected as a subject for the treatment of cancer with a phosphatidylserine synthase 1 inhibitor.
A method for predicting responsiveness to the treatment of cancer with a phosphatidylserine synthase 1 inhibitor, comprising detecting the presence or absence of the functional suppression of phosphatidylserine synthase 2 in the biological sample derived from a subject, and thereby determining that the subject for whom the functional suppression of phosphatidylserine synthase 2 has been detected has responsiveness to the treatment of cancer with a phosphatidylserine synthase 1 inhibitor.
A method for selecting a subject for the treatment of cancer with a phosphatidylserine synthase 1 inhibitor, comprising detecting the presence or absence of the functional suppression of phosphatidylserine synthase 2 in the biological sample derived from a subject, and selecting the subject for whom the functional suppression of phosphatidylserine synthase 2 has been detected as a subject for the treatment of cancer with a phosphatidylserine synthase 1 inhibitor.
Dependencies are inferred from the claim text.